Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon mobility control
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On the Site and Mechanism of Action of β3-Adrenoceptor Agonists in the Bladder
The clinical success of mirabegron as the first β3-adrenoceptor (AR) agonist for treatment of the overactive bladder (OAB) syndrome, has resulted in substantial interest in its site and mechanism of action. Even if the adrenergic innervation of the bladder and urethra has been well studied, the location(s) of β3-ARs in different structures within the bladder wall and urethra, and the mode(s) of...
متن کاملA Clinician’s Perspective on the Mechanism of β3-Adrenoceptor Agonists in the Bladder
Copyright © 2017 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A Clinician’s Perspective on the Mechanism of β3...
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Do β3-adrenoceptor agonists cause urinary bladder smooth muscle relaxation by inhibiting 1 acetylcholine release? 2 Focus on “Inhibition of cholinergic neurotransmission by β3-adrenoceptors depends on 3 adenosine release and A1 receptors activation in human and rat urinary bladder” 4 5 Katerina Okeke, Stavros Gravas, Martin C. Michel 6 7 8 Dept. of Pharmacology, Johannes Gutenberg University, M...
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Administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. In the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. Intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p<O.OOO 1). The u2- ad...
متن کاملImportance and prospects for design of selective muscarinic agonists.
There are five subtypes of muscarinic receptors that serve various important physiological functions in the central nervous system and the periphery. Mental functions like attention, learning, and memory are attributed to the muscarinic M1 subtype. These functions decline during natural aging and an early deficit is typical for Alzheimer s disease. In addition, stimulation of the M1 receptor in...
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ژورنال
عنوان ژورنال: Drugs and Therapy Studies
سال: 2013
ISSN: 2038-9507,2038-9493
DOI: 10.4081/dts.2013.e5